Path ID: DB01005_MESH_D015464_1
Concepts
| Identifier | Name | Type |
|---|---|---|
| MESH:D006918 | Hydroxycarbamide | Drug |
| UniProt:P23921 | Ribonucleoside-diphosphate reductase large subunit | Protein |
| GO:0090592 | DNA synthesis involved in DNA replication | BiologicalProcess |
| HP:0031377 | Abnormal cell proliferation | PhenotypicFeature |
| MESH:D015464 | Chronic myeloid leukemia | Disease |
Relationships
NOTE: predicates are annotated in Biolink Model (v1.3.0)
| Subject | Predicate | Object |
|---|---|---|
| Hydroxycarbamide | DECREASES ACTIVITY OF | Ribonucleoside-Diphosphate Reductase Large Subunit |
| Ribonucleoside-Diphosphate Reductase Large Subunit | POSITIVELY REGULATES | Dna Synthesis Involved In Dna Replication |
| Dna Synthesis Involved In Dna Replication | POSITIVELY CORRELATED WITH | Abnormal Cell Proliferation |
| Abnormal Cell Proliferation | CAUSES | Chronic Myeloid Leukemia |
Reference: