Path ID: DB00997_MESH_D055752_1

db00997-mesh-d055752-1

Concepts

Identifier Name Type
MESH:D004317 doxorubicin Drug
MESH:D006657 Histones ChemicalSubstance
MESH:D005609 Free Radicals ChemicalSubstance
UniProt:P11388 DNA topoisomerase 2-alpha Protein
GO:0006260 DNA replication BiologicalProcess
HP:0031377 Abnormal cell proliferation PhenotypicFeature
UBERON:0002048 lung GrossAnatomicalStructure
GO:0006915 apoptotic process BiologicalProcess
MESH:D055752 Small Cell Lung Carcinoma Disease

Relationships

NOTE: predicates are annotated in Biolink Model (v1.3.0)

Subject Predicate Object
Doxorubicin DECREASES ACTIVITY OF Dna Topoisomerase 2-Alpha
Doxorubicin NEGATIVELY REGULATES Histones
Doxorubicin INCREASES ABUNDANCE OF Free Radicals
Histones POSITIVELY CORRELATED WITH Dna Replication
Dna Topoisomerase 2-Alpha POSITIVELY CORRELATED WITH Dna Replication
Dna Replication POSITIVELY CORRELATED WITH Abnormal Cell Proliferation
Abnormal Cell Proliferation LOCATED IN Lung
Lung LOCATION OF Small Cell Lung Carcinoma
Free Radicals POSITIVELY CORRELATED WITH Apoptotic Process
Apoptotic Process NEGATIVELY CORRELATED WITH Small Cell Lung Carcinoma

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