Path ID: DB00997_MESH_D008224_1

db00997-mesh-d008224-1

Concepts

Identifier Name Type
MESH:D004317 doxorubicin Drug
MESH:D006657 Histones ChemicalSubstance
MESH:D005609 Free Radicals ChemicalSubstance
UniProt:P11388 DNA topoisomerase 2-alpha Protein
GO:0006260 DNA replication BiologicalProcess
HP:0031377 Abnormal cell proliferation PhenotypicFeature
CL:0000236 B cell Cell
GO:0006915 apoptotic process BiologicalProcess
MESH:D008224 Lymphoma, Follicular Disease

Relationships

NOTE: predicates are annotated in Biolink Model (v1.3.0)

Subject Predicate Object
Doxorubicin DECREASES ACTIVITY OF Dna Topoisomerase 2-Alpha
Doxorubicin NEGATIVELY REGULATES Histones
Doxorubicin INCREASES ABUNDANCE OF Free Radicals
Histones POSITIVELY CORRELATED WITH Dna Replication
Dna Topoisomerase 2-Alpha POSITIVELY CORRELATED WITH Dna Replication
Dna Replication POSITIVELY CORRELATED WITH Abnormal Cell Proliferation
Abnormal Cell Proliferation LOCATED IN B Cell
B Cell LOCATION OF Lymphoma, Follicular
Free Radicals POSITIVELY CORRELATED WITH Apoptotic Process
Apoptotic Process NEGATIVELY CORRELATED WITH Lymphoma, Follicular

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