Path ID: DB00988_MESH_D007022_1
Concepts
| Identifier | Name | Type |
|---|---|---|
| MESH:D004298 | dopamine | Drug |
| UniProt:P35348 | Alpha-1A adrenergic receptor | Protein |
| UniProt:P08588 | Beta-1 adrenergic receptor | Protein |
| GO:0060048 | cardiac muscle contraction | BiologicalProcess |
| GO:0042310 | vasoconstriction | BiologicalProcess |
| MESH:D007022 | Low blood pressure | Disease |
Relationships
NOTE: predicates are annotated in Biolink Model (v1.3.0)
| Subject | Predicate | Object |
|---|---|---|
| Dopamine | INCREASES ACTIVITY OF | Alpha-1A Adrenergic Receptor |
| Alpha-1A Adrenergic Receptor | POSITIVELY REGULATES | Vasoconstriction |
| Vasoconstriction | NEGATIVELY CORRELATED WITH | Low Blood Pressure |
| Dopamine | INCREASES ACTIVITY OF | Beta-1 Adrenergic Receptor |
| Beta-1 Adrenergic Receptor | POSITIVELY REGULATES | Cardiac Muscle Contraction |
| Cardiac Muscle Contraction | NEGATIVELY CORRELATED WITH | Low Blood Pressure |
Comment: Dopamine binds to alpha-1 and beta-1 adrenergic receptors. Alpha-1 adrenergic receptor stimulation on vascular smooth muscle leads to vasoconstriction and results in an increase in systemic vascular resistance (https://pubchem.ncbi.nlm.nih.gov/compound/681).
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