Path ID: DB00977_MESH_D000152_1
Concepts
| Identifier | Name | Type |
|---|---|---|
| MESH:D004997 | Ethinylestradiol | Drug |
| UniProt:P03372 | Estrogen receptor alpha | Protein |
| GO:0043627 | Response to estrogen | BiologicalProcess |
| CL:0000317 | Sebum secreting cell | Cell |
| GO:0006702 | Androgen synthesis | BiologicalProcess |
| MESH:D000728 | Androgens | ChemicalSubstance |
| MESH:D000152 | Acne vulgaris | Disease |
Relationships
NOTE: predicates are annotated in Biolink Model (v1.3.0)
| Subject | Predicate | Object |
|---|---|---|
| Ethinylestradiol | INCREASES ACTIVITY OF | Estrogen Receptor Alpha |
| Estrogen Receptor Alpha | PARTICIPATES IN | Response To Estrogen |
| Response To Estrogen | NEGATIVELY REGULATES | Sebum Secreting Cell |
| Response To Estrogen | NEGATIVELY REGULATES | Androgen Synthesis |
| Sebum Secreting Cell | POSITIVELY CORRELATED WITH | Acne Vulgaris |
| Androgen Synthesis | INCREASES ABUNDANCE OF | Androgens |
| Androgens | CONTRIBUTES TO | Acne Vulgaris |
Reference: