Path ID: DB00973_MESH_C537345_1
Concepts
| Identifier | Name | Type |
|---|---|---|
| MESH:D000069438 | ezetimibe | Drug |
| UniProt:Q9UHC9 | NPC1-like intracellular cholesterol transporter 1 | Protein |
| GO:0098856 | intestinal lipid absorption | BiologicalProcess |
| CHEBI:26125 | phytosterols | ChemicalSubstance |
| HP:0033341 | Elevated circulating sitosterol concentration | PhenotypicFeature |
| MESH:C537345 | Sitosterolemia | Disease |
Relationships
NOTE: predicates are annotated in Biolink Model (v1.3.0)
| Subject | Predicate | Object |
|---|---|---|
| Ezetimibe | NEGATIVELY REGULATES | Npc1-Like Intracellular Cholesterol Transporter 1 |
| Npc1-Like Intracellular Cholesterol Transporter 1 | POSITIVELY REGULATES | Intestinal Lipid Absorption |
| Intestinal Lipid Absorption | INCREASES ABUNDANCE OF | Phytosterols |
| Phytosterols | POSITIVELY CORRELATED WITH | Elevated Circulating Sitosterol Concentration |
| Elevated Circulating Sitosterol Concentration | MANIFESTATION OF | Sitosterolemia |
Reference: