Path ID: DB00968_MESH_D006973_1
Concepts
| Identifier | Name | Type |
|---|---|---|
| MESH:D008750 | methyldopa | Drug |
| CHEBI:141146 | α-methylnoradrenaline | ChemicalSubstance |
| UniProt:P08913 | Alpha-2A adrenergic receptor | Protein |
| UniProt:P18089 | Alpha-2B adrenergic receptor | Protein |
| UniProt:P18825 | Alpha-2C adrenergic receptor | Protein |
| GO:0048242 | epinephrine secretion | BiologicalProcess |
| GO:0048243 | norepinephrine secretion | BiologicalProcess |
| GO:0042310 | vasoconstriction | BiologicalProcess |
| HP:0032263 | Increased blood pressure | PhenotypicFeature |
| MESH:D006973 | Hypertensive disorder | Disease |
Relationships
NOTE: predicates are annotated in Biolink Model (v1.3.0)
| Subject | Predicate | Object |
|---|---|---|
| Methyldopa | HAS METABOLITE | Α-Methylnoradrenaline |
| Α-Methylnoradrenaline | INCREASES ACTIVITY OF | Alpha-2A Adrenergic Receptor |
| Α-Methylnoradrenaline | INCREASES ACTIVITY OF | Alpha-2B Adrenergic Receptor |
| Α-Methylnoradrenaline | INCREASES ACTIVITY OF | Alpha-2C Adrenergic Receptor |
| Alpha-2A Adrenergic Receptor | NEGATIVELY REGULATES | Epinephrine Secretion |
| Alpha-2B Adrenergic Receptor | NEGATIVELY REGULATES | Epinephrine Secretion |
| Alpha-2C Adrenergic Receptor | NEGATIVELY REGULATES | Epinephrine Secretion |
| Alpha-2A Adrenergic Receptor | NEGATIVELY REGULATES | Norepinephrine Secretion |
| Alpha-2B Adrenergic Receptor | NEGATIVELY REGULATES | Norepinephrine Secretion |
| Alpha-2C Adrenergic Receptor | NEGATIVELY REGULATES | Norepinephrine Secretion |
| Epinephrine Secretion | POSITIVELY CORRELATED WITH | Vasoconstriction |
| Norepinephrine Secretion | POSITIVELY CORRELATED WITH | Vasoconstriction |
| Vasoconstriction | POSITIVELY CORRELATED WITH | Increased Blood Pressure |
| Increased Blood Pressure | MANIFESTATION OF | Hypertensive Disorder |
Comment: The active metabolite is an agonist of the presynaptic α2-adrenergic receptor in the CNS. These are inhibitory receptors that when activated cause inhibition of neurotransmitter release, which inhibits vasoconstriction.
Reference:
- https://go.drugbank.com/drugs/DB00968
- https://www.ebi.ac.uk/chembl/compound_report_card/CHEMBL459/
- https://en.wikipedia.org/wiki/Methyldopa#Mechanism_of_action
- https://pubchem.ncbi.nlm.nih.gov/compound/38853
- https://en.wikipedia.org/wiki/Corbadrine
- https://meshb.nlm.nih.gov/record/ui?ui=D008771
- https://en.wikipedia.org/wiki/Antihypertensive_drug#Alpha-2_adrenergic_receptor_agonists
- https://en.wikipedia.org/wiki/Adrenaline#Mechanism_of_action
- https://www.rxlist.com/aldomet-drug.htm#clinpharm