Path ID: DB00957_MESH_D019584_1
Concepts
| Identifier | Name | Type |
|---|---|---|
| MESH:C017576 | Norgestimate | Drug |
| UniProt:P06401 | Progesterone receptor | Protein |
| GO:0050847 | Progesterone receptor signaling pathway | BiologicalProcess |
| UniProt:P03372 | Estrogen receptor | Protein |
| GO:0030520 | Intracellular estrogen receptor signaling pathway | BiologicalProcess |
| MESH:D019584 | Menopausal flushing | Disease |
Relationships
NOTE: predicates are annotated in Biolink Model (v1.3.0)
| Subject | Predicate | Object |
|---|---|---|
| Norgestimate | INCREASES ACTIVITY OF | Progesterone Receptor |
| Progesterone Receptor | POSITIVELY REGULATES | Progesterone Receptor Signaling Pathway |
| Progesterone Receptor Signaling Pathway | TREATS | Menopausal Flushing |
| Norgestimate | INCREASES ACTIVITY OF | Estrogen Receptor |
| Estrogen Receptor | POSITIVELY REGULATES | Intracellular Estrogen Receptor Signaling Pathway |
| Intracellular Estrogen Receptor Signaling Pathway | TREATS | Menopausal Flushing |
Comment: Norgestimate is formulated with ethinylestradiol as a combined oral contraceptive . The norgestimate on it’s own is not sufficient for a therapeutic effect.
Reference: