Path ID: DB00957_MESH_D000152_1
Concepts
| Identifier | Name | Type |
|---|---|---|
| MESH:C017576 | Norgestimate | Drug |
| UBERON:0004092 | Hypothalamus-pituitary axis | GrossAnatomicalStructure |
| GO:0006702 | Androgen biosynthetic process | BiologicalProcess |
| MESH:D000728 | Androgens | ChemicalSubstance |
| CL:0000317 | Sebum secreting cell | Cell |
| MESH:D012738 | Sex Hormone-Binding Globulin | ChemicalSubstance |
| MESH:D013739 | Testosterone | ChemicalSubstance |
| MESH:D000152 | Acne vulgaris | Disease |
Relationships
NOTE: predicates are annotated in Biolink Model (v1.3.0)
| Subject | Predicate | Object |
|---|---|---|
| Norgestimate | NEGATIVELY REGULATES | Hypothalamus-Pituitary Axis |
| Hypothalamus-Pituitary Axis | POSITIVELY REGULATES | Androgen Biosynthetic Process |
| Androgen Biosynthetic Process | INCREASES ABUNDANCE OF | Androgens |
| Androgens | POSITIVELY REGULATES | Sebum Secreting Cell |
| Norgestimate | POSITIVELY REGULATES | Sex Hormone-Binding Globulin |
| Sex Hormone-Binding Globulin | DECREASES ABUNDANCE OF | Testosterone |
| Testosterone | POSITIVELY REGULATES | Sebum Secreting Cell |
| Sebum Secreting Cell | POSITIVELY CORRELATED WITH | Acne Vulgaris |
Comment: Norgestimate is formulated with ethinylestradiol as a combined oral contraceptive. The norgestimate on it’s own is not sufficient for a therapeutic effect.
Reference: