Path ID: DB00951_MESH_D014397_1
Concepts
| Identifier | Name | Type |
|---|---|---|
| MESH:D007538 | Isoniazid | Drug |
| UniProt:P9WGR1 | Enoyl-[acyl-carrier-protein] reductase [NADH] (Mycobacterium tuberculosis) | Protein |
| GO:0071768 | Mycolic acid biosynthetic process | BiologicalProcess |
| MESH:D009171 | Mycolic Acids | ChemicalSubstance |
| GO:0071766 | Actinobacterium-type cell wall biogenesis | BiologicalProcess |
| taxonomy:1773 | Mycobacterium tuberculosis | OrganismTaxon |
| MESH:D014397 | Pulmonary tuberculosis | Disease |
Relationships
NOTE: predicates are annotated in Biolink Model (v1.3.0)
| Subject | Predicate | Object |
|---|---|---|
| Isoniazid | DECREASES ACTIVITY OF | Enoyl-[Acyl-Carrier-Protein] Reductase [Nadh] (Mycobacterium Tuberculosis) |
| Enoyl-[Acyl-Carrier-Protein] Reductase [Nadh] (Mycobacterium Tuberculosis) | POSITIVELY REGULATES | Mycolic Acid Biosynthetic Process |
| Mycolic Acid Biosynthetic Process | INCREASES ABUNDANCE OF | Mycolic Acids |
| Mycolic Acids | PARTICIPATES IN | Actinobacterium-Type Cell Wall Biogenesis |
| Actinobacterium-Type Cell Wall Biogenesis | IN TAXON | Mycobacterium Tuberculosis |
| Mycobacterium Tuberculosis | CAUSES | Pulmonary Tuberculosis |
Comment: Isoniazid is a prodrug and must be activated by a bacterial catalase-peroxidase enzyme in Mycobacterium tuberculosis.
Reference: