Path ID: DB00949_MESH_D065768_1
Concepts
| Identifier | Name | Type |
|---|---|---|
| MESH:C047360 | Felbamate | Drug |
| UniProt:Q13224 | Glutamate receptor ionotropic, NMDA 2B | Protein |
| UniProt:Q12879 | Glutamate receptor ionotropic, NMDA | Protein |
| HP:0001250 | Seizure | PhenotypicFeature |
| MESH:D065768 | Lennox-Gastaut syndrome | Disease |
Relationships
NOTE: predicates are annotated in Biolink Model (v1.3.0)
| Subject | Predicate | Object |
|---|---|---|
| Felbamate | DECREASES ACTIVITY OF | Glutamate Receptor Ionotropic, Nmda 2B |
| Felbamate | DECREASES ACTIVITY OF | Glutamate Receptor Ionotropic, Nmda |
| Glutamate Receptor Ionotropic, Nmda 2B | POSITIVELY CORRELATED WITH | Seizure |
| Glutamate Receptor Ionotropic, Nmda | POSITIVELY CORRELATED WITH | Seizure |
| Seizure | MANIFESTATION OF | Lennox-Gastaut Syndrome |
Comment: The mechanism by which felbamate exerts its anticonvulsant activity is not fully known.
Reference: