Path ID: DB00945_MESH_D010003_1
Concepts
| Identifier | Name | Type |
|---|---|---|
| MESH:D001241 | Aspirin | Drug |
| UniProt:P23219 | Prostaglandin G/H synthase 1 | Protein |
| UniProt:P35354 | Prostaglandin G/H synthase 2 | Protein |
| GO:0001516 | prostaglandin biosynthetic process | BiologicalProcess |
| MESH:D011453 | Prostaglandins | ChemicalSubstance |
| GO:0006954 | inflammatory response | BiologicalProcess |
| MESH:D010003 | Osteoarthritis | Disease |
Relationships
NOTE: predicates are annotated in Biolink Model (v1.3.0)
| Subject | Predicate | Object |
|---|---|---|
| Aspirin | DECREASES ACTIVITY OF | Prostaglandin G/H Synthase 1 |
| Aspirin | DECREASES ACTIVITY OF | Prostaglandin G/H Synthase 2 |
| Prostaglandin G/H Synthase 1 | POSITIVELY REGULATES | Prostaglandin Biosynthetic Process |
| Prostaglandin G/H Synthase 2 | POSITIVELY REGULATES | Prostaglandin Biosynthetic Process |
| Prostaglandin Biosynthetic Process | INCREASES ABUNDANCE OF | Prostaglandins |
| Prostaglandins | CONTRIBUTES TO | Inflammatory Response |
| Inflammatory Response | POSITIVELY CORRELATED WITH | Osteoarthritis |
Reference: