Path ID: DB00932_MESH_D015658_1
Concepts
| Identifier | Name | Type |
|---|---|---|
| MESH:C107201 | tipranavir | Drug |
| UniProt:Q72874 | Human immunodeficiency virus type 1 protease | Protein |
| UniProt:P04591 | Gag polyprotein | Protein |
| UniProt:P04585 | Gag-Pol polyprotein | Protein |
| GO:0019068 | virion assembly | BiologicalProcess |
| taxonomy:11676 | Human immunodeficiency virus 1 | OrganismTaxon |
| MESH:D015658 | Human immunodeficiency virus infection | Disease |
Relationships
NOTE: predicates are annotated in Biolink Model (v1.3.0)
| Subject | Predicate | Object |
|---|---|---|
| Tipranavir | DECREASES ACTIVITY OF | Human Immunodeficiency Virus Type 1 Protease |
| Human Immunodeficiency Virus Type 1 Protease | INCREASES ACTIVITY OF | Gag Polyprotein |
| Human Immunodeficiency Virus Type 1 Protease | INCREASES ACTIVITY OF | Gag-Pol Polyprotein |
| Gag Polyprotein | PARTICIPATES IN | Virion Assembly |
| Gag-Pol Polyprotein | PARTICIPATES IN | Virion Assembly |
| Virion Assembly | IN TAXON | Human Immunodeficiency Virus 1 |
| Human Immunodeficiency Virus 1 | CAUSES | Human Immunodeficiency Virus Infection |
Comment: Tipranavir should only be taken in combination with ritonavir and other antiretroviral drugs, and is not approved for treatment-naïve patients (https://en.wikipedia.org/wiki/Tipranavir)
Reference: