Path ID: DB00924_MESH_D009128_1
Concepts
| Identifier | Name | Type |
|---|---|---|
| MESH:C004704 | cyclobenzaprine | Drug |
| UniProt:P28223 | 5-hydroxytryptamine receptor 2A | Protein |
| UniProt:P28335 | 5-hydroxytryptamine receptor 2C | Protein |
| GO:0060096 | Serotonin secretion, neurotransmission | BiologicalProcess |
| GO:0050883 | musculoskeletal movement, spinal reflex action | BiologicalProcess |
| UBERON:0025593 | serotonergic system | GrossAnatomicalStructure |
| UBERON:0002240 | spinal cord | GrossAnatomicalStructure |
| HP:0031826 | Abnormal reflex | PhenotypicFeature |
| HP:0003394 | Muscle spasm | PhenotypicFeature |
| MESH:D009128 | Spasticity | Disease |
Relationships
NOTE: predicates are annotated in Biolink Model (v1.3.0)
| Subject | Predicate | Object |
|---|---|---|
| Cyclobenzaprine | DECREASES ACTIVITY OF | 5-Hydroxytryptamine Receptor 2A |
| Cyclobenzaprine | DECREASES ACTIVITY OF | 5-Hydroxytryptamine Receptor 2C |
| 5-Hydroxytryptamine Receptor 2A | PARTICIPATES IN | Serotonin Secretion, Neurotransmission |
| 5-Hydroxytryptamine Receptor 2C | PARTICIPATES IN | Serotonin Secretion, Neurotransmission |
| Serotonin Secretion, Neurotransmission | PART OF | Serotonergic System |
| Serotonergic System | LOCATED IN | Spinal Cord |
| Spinal Cord | POSITIVELY REGULATES | Musculoskeletal Movement, Spinal Reflex Action |
| Musculoskeletal Movement, Spinal Reflex Action | CORRELATED WITH | Abnormal Reflex |
| Abnormal Reflex | PRECEDES | Muscle Spasm |
| Muscle Spasm | MANIFESTATION OF | Spasticity |
Comment: Cyclobenzaprine is a skeletal muscle relaxant that works on areas of the brainstem to reduce skeletal muscle spasm, though its exact pharmacodynamic behaviour is currently unclear.
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