Path ID: DB00922_MESH_D006333_1
Concepts
| Identifier | Name | Type |
|---|---|---|
| MESH:C076731 | Levosimendan | Drug |
| UniProt:P63316 | Troponin C, slow skeletal and cardiac muscles | Protein |
| GO:0060047 | Heart contraction | BiologicalProcess |
| UniProt:Q15842 | ATP-sensitive inward rectifier potassium channel 8 | Protein |
| UniProt:Q14654 | ATP-sensitive inward rectifier potassium channel 11 | Protein |
| GO:0044557 | Relaxation of smooth muscle | BiologicalProcess |
| GO:0042311 | Vasodilation | BiologicalProcess |
| HP:0000822 | Hypertension | PhenotypicFeature |
| MESH:D006333 | Congestive heart failure | Disease |
Relationships
NOTE: predicates are annotated in Biolink Model (v1.3.0)
| Subject | Predicate | Object |
|---|---|---|
| Levosimendan | INCREASES STABILITY OF | Troponin C, Slow Skeletal And Cardiac Muscles |
| Troponin C, Slow Skeletal And Cardiac Muscles | POSITIVELY REGULATES | Heart Contraction |
| Heart Contraction | NEGATIVELY CORRELATED WITH | Congestive Heart Failure |
| Levosimendan | INCREASES ACTIVITY OF | Atp-Sensitive Inward Rectifier Potassium Channel 11 |
| Levosimendan | INCREASES ACTIVITY OF | Atp-Sensitive Inward Rectifier Potassium Channel 8 |
| Atp-Sensitive Inward Rectifier Potassium Channel 11 | POSITIVELY REGULATES | Relaxation Of Smooth Muscle |
| Atp-Sensitive Inward Rectifier Potassium Channel 8 | POSITIVELY REGULATES | Relaxation Of Smooth Muscle |
| Relaxation Of Smooth Muscle | POSITIVELY REGULATES | Vasodilation |
| Vasodilation | NEGATIVELY CORRELATED WITH | Hypertension |
| Hypertension | AFFECTS RISK FOR | Congestive Heart Failure |
Comment: Levosimendan has not been approved for use in the U.S. or Canada. It has been reported that levosimendan may act preferentially as a Ca2+ sensitizer at lower concentrations.
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