Path ID: DB00918_MESH_D008881_1
Concepts
| Identifier | Name | Type |
|---|---|---|
| MESH:C409045 | Almotriptan | Drug |
| UniProt:P28222 | 5-hydroxytryptamine receptor 1B | Protein |
| UniProt:P28221 | 5-hydroxytryptamine receptor 1D | Protein |
| GO:0042310 | Vasoconstriction | BiologicalProcess |
| MESH:D020078 | Neurogenic Inflammation | Disease |
| UBERON:0001645 | Trigeminal nerve | GrossAnatomicalStructure |
| GO:0019233 | Sensory perception of pain | BiologicalProcess |
| MESH:D010146 | Pain | Disease |
| MESH:D008881 | Migraine | Disease |
Relationships
NOTE: predicates are annotated in Biolink Model (v1.3.0)
| Subject | Predicate | Object |
|---|---|---|
| Almotriptan | INCREASES ACTIVITY OF | 5-Hydroxytryptamine Receptor 1B |
| Almotriptan | INCREASES ACTIVITY OF | 5-Hydroxytryptamine Receptor 1D |
| 5-Hydroxytryptamine Receptor 1B | POSITIVELY REGULATES | Vasoconstriction |
| Vasoconstriction | NEGATIVELY REGULATES | Pain |
| Pain | POSITIVELY CORRELATED WITH | Migraine |
| 5-Hydroxytryptamine Receptor 1B | NEGATIVELY REGULATES | Neurogenic Inflammation |
| 5-Hydroxytryptamine Receptor 1D | NEGATIVELY REGULATES | Neurogenic Inflammation |
| Neurogenic Inflammation | POSITIVELY CORRELATED WITH | Migraine |
| 5-Hydroxytryptamine Receptor 1B | DECREASES ACTIVITY OF | Trigeminal Nerve |
| 5-Hydroxytryptamine Receptor 1D | DECREASES ACTIVITY OF | Trigeminal Nerve |
| Trigeminal Nerve | PARTICIPATES IN | Sensory Perception Of Pain |
| Sensory Perception Of Pain | POSITIVELY CORRELATED WITH | Migraine |
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