Path ID: DB00903_MESH_D004487_1

db00903-mesh-d004487-1

Concepts

Identifier Name Type
MESH:D004976 ethacrynic acid Drug
UniProt:Q13621 Solute carrier family 12 member 1 Protein
GO:0008511 sodium:potassium:chloride symporter activity MolecularActivity
GO:0035812 renal sodium excretion BiologicalProcess
GO:0036359 renal potassium excretion BiologicalProcess
GO:0003092 renal water retention BiologicalProcess
MESH:D004487 Edema Disease

Relationships

NOTE: predicates are annotated in Biolink Model (v1.3.0)

Subject Predicate Object
Ethacrynic Acid NEGATIVELY REGULATES Solute Carrier Family 12 Member 1
Solute Carrier Family 12 Member 1 POSITIVELY REGULATES Sodium:Potassium:Chloride Symporter Activity
Sodium:Potassium:Chloride Symporter Activity NEGATIVELY CORRELATED WITH Renal Potassium Excretion
Sodium:Potassium:Chloride Symporter Activity NEGATIVELY CORRELATED WITH Renal Sodium Excretion
Renal Potassium Excretion NEGATIVELY CORRELATED WITH Renal Water Retention
Renal Sodium Excretion NEGATIVELY CORRELATED WITH Renal Water Retention
Renal Water Retention CONTRIBUTES TO Edema

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