Path ID: DB00901_MESH_D011656_1
Concepts
| Identifier | Name | Type |
|---|---|---|
| MESH:C011685 | bitolterol | Drug |
| UniProt:P07550 | Beta-2 adrenergic receptor | Protein |
| GO:0071871 | response to epinephrine | BiologicalProcess |
| UniProt:B7Z2C7 | Adenylate cyclase | Protein |
| CHEBI:17489 | 3’,5’-cyclic AMP | ChemicalSubstance |
| GO:0070509 | transmembrane calcium influx | BiologicalProcess |
| GO:0006939 | smooth muscle contraction | BiologicalProcess |
| UBERON:0002187 | terminal bronchiole | GrossAnatomicalStructure |
| GO:0006954 | inflammatory response | BiologicalProcess |
| MESH:D011656 | Pulmonary emphysema | Disease |
Relationships
NOTE: predicates are annotated in Biolink Model (v1.3.0)
| Subject | Predicate | Object |
|---|---|---|
| Bitolterol | INCREASES ACTIVITY OF | Beta-2 Adrenergic Receptor |
| Beta-2 Adrenergic Receptor | PARTICIPATES IN | Response To Epinephrine |
| Response To Epinephrine | POSITIVELY REGULATES | Adenylate Cyclase |
| Adenylate Cyclase | INCREASES ABUNDANCE OF | 3’,5’-Cyclic Amp |
| 3’,5’-Cyclic Amp | NEGATIVELY REGULATES | Transmembrane Calcium Influx |
| Transmembrane Calcium Influx | CONTRIBUTES TO | Smooth Muscle Contraction |
| Smooth Muscle Contraction | LOCATED IN | Terminal Bronchiole |
| Terminal Bronchiole | LOCATION OF | Inflammatory Response |
| Inflammatory Response | CAUSES | Pulmonary Emphysema |
Reference: