Path ID: DB00883_MESH_D000787_1
Concepts
| Identifier | Name | Type |
|---|---|---|
| MESH:D007548 | Isosorbide Dinitrate | Drug |
| MESH:D009569 | Nitric Oxide | ChemicalSubstance |
| UniProt:P16066 | Atrial natriuretic peptide receptor 1 | Protein |
| MESH:D006152 | Cyclic GMP | ChemicalSubstance |
| UniProt:Q13976 | cGMP-dependent protein kinase 1 | Protein |
| GO:0050115 | myosin-light-chain-phosphatase activity | MolecularActivity |
| GO:0044557 | relaxation of smooth muscle | BiologicalProcess |
| MESH:D000787 | Angina Pectoris | Disease |
Relationships
NOTE: predicates are annotated in Biolink Model (v1.3.0)
| Subject | Predicate | Object |
|---|---|---|
| Isosorbide Dinitrate | HAS METABOLITE | Nitric Oxide |
| Nitric Oxide | INCREASES ACTIVITY OF | Atrial Natriuretic Peptide Receptor 1 |
| Atrial Natriuretic Peptide Receptor 1 | INCREASES ABUNDANCE OF | Cyclic Gmp |
| Cyclic Gmp | INCREASES ACTIVITY OF | Cgmp-Dependent Protein Kinase 1 |
| Cgmp-Dependent Protein Kinase 1 | REGULATES | Myosin-Light-Chain-Phosphatase Activity |
| Myosin-Light-Chain-Phosphatase Activity | POSITIVELY REGULATES | Relaxation Of Smooth Muscle |
| Relaxation Of Smooth Muscle | NEGATIVELY CORRELATED WITH | Angina Pectoris |
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