Path ID: DB00880_MESH_D004487_1
Concepts
| Identifier | Name | Type |
|---|---|---|
| MESH:D002740 | chlorothiazide | Drug |
| UniProt:P55017 | Solute carrier family 12 member 3 | Protein |
| GO:0015378 | sodium:chloride symporter activity | MolecularActivity |
| GO:0035812 | renal sodium excretion | BiologicalProcess |
| GO:0003092 | renal water retention | BiologicalProcess |
| MESH:D004487 | Edema | Disease |
Relationships
NOTE: predicates are annotated in Biolink Model (v1.3.0)
| Subject | Predicate | Object |
|---|---|---|
| Chlorothiazide | DECREASES ACTIVITY OF | Solute Carrier Family 12 Member 3 |
| Solute Carrier Family 12 Member 3 | POSITIVELY REGULATES | Sodium:Chloride Symporter Activity |
| Sodium:Chloride Symporter Activity | PARTICIPATES IN | Renal Sodium Excretion |
| Renal Sodium Excretion | POSITIVELY CORRELATED WITH | Renal Water Retention |
| Renal Water Retention | POSITIVELY CORRELATED WITH | Edema |
Reference: