Path ID: DB00875_MESH_D012559_1
Concepts
| Identifier | Name | Type |
|---|---|---|
| MESH:D005475 | Flupentixol | Drug |
| UniProt:P14416 | D(2) dopamine receptor | Protein |
| reactome:R-HSA-390651 | Dopamine receptors | Pathway |
| MESH:D012559 | Schizophrenia | Disease |
Relationships
NOTE: predicates are annotated in Biolink Model (v1.3.0)
| Subject | Predicate | Object |
|---|---|---|
| Flupentixol | DECREASES ACTIVITY OF | D(2) Dopamine Receptor |
| D(2) Dopamine Receptor | POSITIVELY CORRELATED WITH | Dopamine Receptors |
| Dopamine Receptors | CORRELATED WITH | Schizophrenia |
Comment: Flupentixol is not approved for use in the United States. Flupentixol exists in two geometric isomers, the trans(E) and pharmacologically active cis(Z) forms.It is generally understood that positive symptoms of schizophrenia arise from a dysregulated striatal dopamine pathway, leading to hyperstimulation of D2 receptors.
Reference: