Path ID: DB00871_MESH_D015352_1
Concepts
| Identifier | Name | Type |
|---|---|---|
| MESH:D013726 | terbutaline | Drug |
| UniProt:P13945 | Beta-3 adrenergic receptor | Protein |
| UniProt:P07550 | Beta-2 adrenergic receptor | Protein |
| GO:0050728 | negative regulation of inflammatory response | BiologicalProcess |
| MESH:D015352 | Tear film insufficiency | Disease |
Relationships
NOTE: predicates are annotated in Biolink Model (v1.3.0)
| Subject | Predicate | Object |
|---|---|---|
| Terbutaline | POSITIVELY REGULATES | Beta-3 Adrenergic Receptor |
| Terbutaline | POSITIVELY REGULATES | Beta-2 Adrenergic Receptor |
| Beta-3 Adrenergic Receptor | POSITIVELY CORRELATED WITH | Negative Regulation Of Inflammatory Response |
| Beta-2 Adrenergic Receptor | POSITIVELY CORRELATED WITH | Negative Regulation Of Inflammatory Response |
| Negative Regulation Of Inflammatory Response | NEGATIVELY CORRELATED WITH | Tear Film Insufficiency |
Comment: DrugBank has this drug as a beta 1 antagonist but data elsewhere does not seem to support the anatagonism role (e.g. https://www.drugs.com/pro/terbutaline.html#s-34090-1, https://www.ebi.ac.uk/chembldb/index.php/compound/inspect/CHEMBL1760 https://www.genome.jp/dbget-bin/www_bget?cpd:C07129))
Reference: