Path ID: DB00869_MESH_D009798_1
Concepts
| Identifier | Name | Type |
|---|---|---|
| MESH:C062765 | dorzolamide | Drug |
| UniProt:P00918 | Carbonic anhydrase 2 | Protein |
| GO:0015701 | bicarbonate transport | BiologicalProcess |
| UBERON:0001796 | aqueous humor of eyeball | GrossAnatomicalStructure |
| MESH:D009798 | Ocular hypertension | Disease |
Relationships
NOTE: predicates are annotated in Biolink Model (v1.3.0)
| Subject | Predicate | Object |
|---|---|---|
| Dorzolamide | NEGATIVELY REGULATES | Carbonic Anhydrase 2 |
| Carbonic Anhydrase 2 | POSITIVELY REGULATES | Bicarbonate Transport |
| Bicarbonate Transport | INCREASES ABUNDANCE OF | Aqueous Humor Of Eyeball |
| Aqueous Humor Of Eyeball | POSITIVELY CORRELATED WITH | Ocular Hypertension |
Reference:
- https://www.ebi.ac.uk/chembl/compound_report_card/CHEMBL218490/
- https://pubchem.ncbi.nlm.nih.gov/compound/5284549#section=Mechanism-of-Action
- https://en.wikipedia.org/wiki/Glaucoma#Medication
- https://www.aaopt.org/docs/knowledge-base/outline26514.doc?sfvrsn=5f863d3_0
- https://en.wikipedia.org/wiki/Aqueous_humour#Clinical_significance