Path ID: DB00860_MESH_D015863_1
Concepts
| Identifier | Name | Type |
|---|---|---|
| MESH:D011239 | prednisolone | Drug |
| UniProt:P04150 | Glucocorticoid receptor | Protein |
| UniProt:P04083 | Annexin A1 | Protein |
| UniProt:P47712 | Cytosolic phospholipase A2 | Protein |
| UniProt:P23219 | Prostaglandin G/H synthase 1 | Protein |
| UniProt:P35354 | Prostaglandin G/H synthase 2 | Protein |
| GO:0019370 | leukotriene biosynthetic process | BiologicalProcess |
| GO:0001516 | prostaglandin biosynthetic process | BiologicalProcess |
| GO:0006954 | inflammatory response | BiologicalProcess |
| UBERON:0001769 | iris | GrossAnatomicalStructure |
| MESH:D015863 | Iridocyclitis | Disease |
Relationships
NOTE: predicates are annotated in Biolink Model (v1.3.0)
| Subject | Predicate | Object |
|---|---|---|
| Prednisolone | INCREASES ACTIVITY OF | Glucocorticoid Receptor |
| Glucocorticoid Receptor | INCREASES ACTIVITY OF | Annexin A1 |
| Glucocorticoid Receptor | DECREASES ACTIVITY OF | Prostaglandin G/H Synthase 1 |
| Glucocorticoid Receptor | DECREASES ACTIVITY OF | Prostaglandin G/H Synthase 2 |
| Annexin A1 | DECREASES ACTIVITY OF | Cytosolic Phospholipase A2 |
| Prostaglandin G/H Synthase 1 | POSITIVELY REGULATES | Prostaglandin Biosynthetic Process |
| Prostaglandin G/H Synthase 2 | POSITIVELY REGULATES | Prostaglandin Biosynthetic Process |
| Cytosolic Phospholipase A2 | POSITIVELY REGULATES | Leukotriene Biosynthetic Process |
| Cytosolic Phospholipase A2 | POSITIVELY REGULATES | Prostaglandin Biosynthetic Process |
| Leukotriene Biosynthetic Process | POSITIVELY CORRELATED WITH | Inflammatory Response |
| Prostaglandin Biosynthetic Process | POSITIVELY CORRELATED WITH | Inflammatory Response |
| Inflammatory Response | LOCATED IN | Iris |
| Iris | LOCATION OF | Iridocyclitis |
Reference: