Path ID: DB00850_MESH_D012559_1
Concepts
| Identifier | Name | Type |
|---|---|---|
| MESH:D010546 | perphenazine | Drug |
| UniProt:P14416 | D(2) dopamine receptor | Protein |
| UniProt:P21728 | D(1A) dopamine receptor | Protein |
| GO:0014046 | dopamine secretion | BiologicalProcess |
| CHEBI:18243 | dopamine | ChemicalSubstance |
| UBERON:0001910 | medial forebrain bundle | GrossAnatomicalStructure |
| HP:0000746 | Delusions | PhenotypicFeature |
| MESH:D012559 | Schizophrenia | Disease |
Relationships
NOTE: predicates are annotated in Biolink Model (v1.3.0)
| Subject | Predicate | Object |
|---|---|---|
| Perphenazine | DECREASES ACTIVITY OF | D(2) Dopamine Receptor |
| Perphenazine | DECREASES ACTIVITY OF | D(1A) Dopamine Receptor |
| D(2) Dopamine Receptor | POSITIVELY REGULATES | Dopamine Secretion |
| D(1A) Dopamine Receptor | POSITIVELY REGULATES | Dopamine Secretion |
| Dopamine Secretion | INCREASES ABUNDANCE OF | Dopamine |
| Dopamine | LOCATED IN | Medial Forebrain Bundle |
| Medial Forebrain Bundle | CORRELATED WITH | Delusions |
| Delusions | MANIFESTATION OF | Schizophrenia |
Reference: