Path ID: DB00849_MESH_D004830_1
Concepts
| Identifier | Name | Type |
|---|---|---|
| MESH:D008618 | methylphenobarbital | Drug |
| InterPro:IPR006028 | Gamma-aminobutyric acid A receptor/Glycine receptor alpha | GeneFamily |
| GO:0022851 | GABA-gated chloride ion channel activity | MolecularActivity |
| GO:0060081 | membrane hyperpolarization | BiologicalProcess |
| GO:0061535 | glutamate secretion, neurotransmission | BiologicalProcess |
| HP:0032792 | Tonic seizure | PhenotypicFeature |
| MESH:D004830 | Tonic-clonic epilepsy | Disease |
Relationships
NOTE: predicates are annotated in Biolink Model (v1.3.0)
| Subject | Predicate | Object |
|---|---|---|
| Methylphenobarbital | INCREASES ACTIVITY OF | Gamma-Aminobutyric Acid A Receptor/Glycine Receptor Alpha |
| Gamma-Aminobutyric Acid A Receptor/Glycine Receptor Alpha | POSITIVELY REGULATES | Gaba-Gated Chloride Ion Channel Activity |
| Gaba-Gated Chloride Ion Channel Activity | POSITIVELY CORRELATED WITH | Membrane Hyperpolarization |
| Membrane Hyperpolarization | NEGATIVELY CORRELATED WITH | Glutamate Secretion, Neurotransmission |
| Glutamate Secretion, Neurotransmission | CORRELATED WITH | Tonic Seizure |
| Tonic Seizure | MANIFESTATION OF | Tonic-Clonic Epilepsy |
Comment: Methylphenobarbital is the N-methylated analogue of phenobarbital, therefore both have similar indications, therapeutic value, and tolerability.
Reference:
- https://en.wikipedia.org/wiki/Methylphenobarbital
- https://go.drugbank.com/drugs/DB00849
- https://pubchem.ncbi.nlm.nih.gov/compound/8271#section=Mechanism-of-Action
- https://en.wikipedia.org/wiki/Phenobarbital#Mechanism_of_action
- https://en.wikipedia.org/wiki/Phenobarbital#History
- https://www.ncbi.nlm.nih.gov/books/NBK2510/