Path ID: DB00845_MESH_D017511_1
Concepts
| Identifier | Name | Type |
|---|---|---|
| MESH:D002991 | clofazimine | Drug |
| UniProt:P22001 | Potassium voltage-gated channel subfamily A member 3 | Protein |
| GO:0005244 | voltage-gated ion channel activity | MolecularActivity |
| reactome:R-HSA-2025928 | Calcineurin activates NFAT | Pathway |
| GO:0006954 | inflammatory response | BiologicalProcess |
| MESH:D017511 | Pyoderma gangrenosum | Disease |
Relationships
NOTE: predicates are annotated in Biolink Model (v1.3.0)
| Subject | Predicate | Object |
|---|---|---|
| Clofazimine | DECREASES ACTIVITY OF | Potassium Voltage-Gated Channel Subfamily A Member 3 |
| Potassium Voltage-Gated Channel Subfamily A Member 3 | POSITIVELY REGULATES | Voltage-Gated Ion Channel Activity |
| Voltage-Gated Ion Channel Activity | POSITIVELY REGULATES | Calcineurin Activates Nfat |
| Calcineurin Activates Nfat | POSITIVELY CORRELATED WITH | Inflammatory Response |
| Inflammatory Response | POSITIVELY CORRELATED WITH | Pyoderma Gangrenosum |
Reference: