Path ID: DB00832_MESH_D004832_1
Concepts
| Identifier | Name | Type |
|---|---|---|
| MESH:C100129 | Phensuximide | Drug |
| UniProt:O43497 | Voltage-dependent T-type calcium channel subunit alpha-1G | Protein |
| GO:0070509 | Calcium ion import | BiologicalProcess |
| GO:0019228 | Neuronal action potential | BiologicalProcess |
| UBERON:0000955 | Brain | GrossAnatomicalStructure |
| MESH:D004832 | Absence seizure | Disease |
Relationships
NOTE: predicates are annotated in Biolink Model (v1.3.0)
| Subject | Predicate | Object |
|---|---|---|
| Phensuximide | DECREASES ACTIVITY OF | Voltage-Dependent T-Type Calcium Channel Subunit Alpha-1G |
| Voltage-Dependent T-Type Calcium Channel Subunit Alpha-1G | POSITIVELY REGULATES | Calcium Ion Import |
| Calcium Ion Import | POSITIVELY REGULATES | Neuronal Action Potential |
| Neuronal Action Potential | LOCATED IN | Brain |
| Brain | POSITIVELY CORRELATED WITH | Absence Seizure |
Comment: Phensuximide is an anticonvulsant in the succinimide class. Discontinued. https://www.accessdata.fda.gov/scripts/cder/daf/index.cfm?event=overview.process&ApplNo=008855
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