Path ID: DB00830_MESH_D009765_1
Concepts
| Identifier | Name | Type |
|---|---|---|
| MESH:D010633 | phenmetrazine | Drug |
| UniProt:Q01959 | Sodium-dependent dopamine transporter | Protein |
| UniProt:P23975 | Sodium-dependent noradrenaline transporter | Protein |
| GO:0051583 | dopamine uptake involved in synaptic transmission | BiologicalProcess |
| UBERON:0004092 | hypothalamus-pituitary axis | GrossAnatomicalStructure |
| HP:0100738 | Abnormal eating behavior | PhenotypicFeature |
| HP:0004324 | Increased body weight | PhenotypicFeature |
| MESH:D009765 | Obesity | Disease |
Relationships
NOTE: predicates are annotated in Biolink Model (v1.3.0)
| Subject | Predicate | Object |
|---|---|---|
| Phenmetrazine | NEGATIVELY REGULATES | Sodium-Dependent Noradrenaline Transporter |
| Phenmetrazine | NEGATIVELY REGULATES | Sodium-Dependent Dopamine Transporter |
| Sodium-Dependent Noradrenaline Transporter | POSITIVELY CORRELATED WITH | Dopamine Uptake Involved In Synaptic Transmission |
| Sodium-Dependent Dopamine Transporter | POSITIVELY CORRELATED WITH | Dopamine Uptake Involved In Synaptic Transmission |
| Dopamine Uptake Involved In Synaptic Transmission | LOCATED IN | Hypothalamus-Pituitary Axis |
| Hypothalamus-Pituitary Axis | CORRELATED WITH | Abnormal Eating Behavior |
| Abnormal Eating Behavior | CORRELATED WITH | Increased Body Weight |
| Increased Body Weight | MANIFESTATION OF | Obesity |
Comment: Withdrawn
Reference: