Path ID: DB00811_MESH_D019698_1
Concepts
| Identifier | Name | Type |
|---|---|---|
| MESH:D012254 | ribavirin | Drug |
| UniProt:Q96885 | RNA-directed RNA polymerase (Hepatitis C virus) | Protein |
| InterPro:IPR019602 | mRNA capping enzyme, large subunit, ATPase/guanylyltransferase, virus | GeneFamily |
| UniProt:P20839 | Inosine-5’-monophosphate dehydrogenase 1 | Protein |
| GO:0039694 | viral RNA genome replication | BiologicalProcess |
| GO:0004484 | mRNA capping enzyme activity | BiologicalProcess |
| GO:0006183 | GTP biosynthetic process | BiologicalProcess |
| taxonomy:11103 | Hepacivirus C | OrganismTaxon |
| MESH:D006160 | Guanosine Triphosphate (GTP) | ChemicalSubstance |
| MESH:D019698 | Chronic hepatitis C | Disease |
| GO:0039694 | viral RNA genome replication | BiologicalProcess |
Relationships
NOTE: predicates are annotated in Biolink Model (v1.3.0)
| Subject | Predicate | Object |
|---|---|---|
| Ribavirin | DECREASES ACTIVITY OF | Rna-Directed Rna Polymerase (Hepatitis C Virus) |
| Ribavirin | NEGATIVELY REGULATES | Mrna Capping Enzyme, Large Subunit, Atpase/Guanylyltransferase, Virus |
| Ribavirin | DECREASES ACTIVITY OF | Inosine-5’-Monophosphate Dehydrogenase 1 |
| Rna-Directed Rna Polymerase (Hepatitis C Virus) | PARTICIPATES IN | Viral Rna Genome Replication |
| Mrna Capping Enzyme, Large Subunit, Atpase/Guanylyltransferase, Virus | PARTICIPATES IN | Mrna Capping Enzyme Activity |
| Inosine-5’-Monophosphate Dehydrogenase 1 | POSITIVELY CORRELATED WITH | Gtp Biosynthetic Process |
| Viral Rna Genome Replication | OCCURS IN | Hepacivirus C |
| Gtp Biosynthetic Process | PRODUCES | Guanosine Triphosphate (Gtp) |
| Guanosine Triphosphate (Gtp) | PARTICIPATES IN | Viral Rna Genome Replication |
| Mrna Capping Enzyme Activity | OCCURS IN | Hepacivirus C |
| Viral Rna Genome Replication | OCCURS IN | Hepacivirus C |
| Hepacivirus C | CAUSES | Chronic Hepatitis C |
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