Path ID: DB00799_MESH_D011565_1
Concepts
| Identifier | Name | Type |
|---|---|---|
| MESH:C086827 | tazarotene | Drug |
| UniProt:P10276 | Retinoic acid receptor alpha | Protein |
| UniProt:P10826 | Retinoic acid receptor beta | Protein |
| UniProt:P28702 | Retinoic acid receptor RXR-beta | Protein |
| UniProt:P13631 | Retinoic acid receptor gamma | Protein |
| MESH:D003873 | Dermatitis, Exfoliative | PhenotypicFeature |
| GO:0043616 | keratinocyte proliferation | BiologicalProcess |
| MESH:D057705 | Transendothelial Migration Pathway | BiologicalProcess |
| GO:0006954 | inflammatory response | BiologicalProcess |
| MESH:D011565 | Psoriasis | Disease |
Relationships
NOTE: predicates are annotated in Biolink Model (v1.3.0)
| Subject | Predicate | Object |
|---|---|---|
| Tazarotene | INCREASES ACTIVITY OF | Retinoic Acid Receptor Alpha |
| Tazarotene | INCREASES ACTIVITY OF | Retinoic Acid Receptor Rxr-Beta |
| Tazarotene | INCREASES ACTIVITY OF | Retinoic Acid Receptor Gamma |
| Tazarotene | INCREASES ACTIVITY OF | Retinoic Acid Receptor Beta |
| Retinoic Acid Receptor Alpha | NEGATIVELY CORRELATED WITH | Keratinocyte Proliferation |
| Retinoic Acid Receptor Rxr-Beta | NEGATIVELY CORRELATED WITH | Keratinocyte Proliferation |
| Retinoic Acid Receptor Gamma | NEGATIVELY CORRELATED WITH | Keratinocyte Proliferation |
| Retinoic Acid Receptor Beta | NEGATIVELY CORRELATED WITH | Keratinocyte Proliferation |
| Retinoic Acid Receptor Alpha | NEGATIVELY CORRELATED WITH | Transendothelial Migration Pathway |
| Retinoic Acid Receptor Rxr-Beta | NEGATIVELY CORRELATED WITH | Transendothelial Migration Pathway |
| Retinoic Acid Receptor Gamma | NEGATIVELY CORRELATED WITH | Transendothelial Migration Pathway |
| Retinoic Acid Receptor Beta | NEGATIVELY CORRELATED WITH | Transendothelial Migration Pathway |
| Retinoic Acid Receptor Alpha | NEGATIVELY CORRELATED WITH | Dermatitis, Exfoliative |
| Retinoic Acid Receptor Rxr-Beta | NEGATIVELY CORRELATED WITH | Dermatitis, Exfoliative |
| Retinoic Acid Receptor Gamma | NEGATIVELY CORRELATED WITH | Dermatitis, Exfoliative |
| Retinoic Acid Receptor Beta | NEGATIVELY CORRELATED WITH | Dermatitis, Exfoliative |
| Transendothelial Migration Pathway | POSITIVELY CORRELATED WITH | Inflammatory Response |
| Keratinocyte Proliferation | POSITIVELY CORRELATED WITH | Psoriasis |
| Inflammatory Response | POSITIVELY CORRELATED WITH | Psoriasis |
| Dermatitis, Exfoliative | POSITIVELY CORRELATED WITH | Psoriasis |
Comment: MESH:D057705 refers to the movement of leukocytes (the term NCIT:C91439 would have been better suited here but could not be validated)
Reference: