Path ID: DB00799_MESH_D000152_1
Concepts
| Identifier | Name | Type |
|---|---|---|
| MESH:C086827 | tazarotene | Drug |
| UniProt:P10276 | Retinoic acid receptor alpha | Protein |
| UniProt:P10826 | Retinoic acid receptor beta | Protein |
| UniProt:P28702 | Retinoic acid receptor RXR-beta | Protein |
| UniProt:P13631 | Retinoic acid receptor gamma | Protein |
| MESH:D053536 | Keratin-16 | Protein |
| MESH:D053553 | Keratin-6 | Protein |
| MESH:D020782 | Matrix Metalloproteinases | Protein |
| UniProt:P00533 | Epidermal growth factor receptor | Protein |
| GO:0006954 | inflammatory response | BiologicalProcess |
| HP:0025249 | Comedo | PhenotypicFeature |
| reactome:R-HSA-181438 | Toll Like Receptor 2 (TLR2) Cascade | Pathway |
| MESH:D000152 | Acne vulgaris | Disease |
Relationships
NOTE: predicates are annotated in Biolink Model (v1.3.0)
| Subject | Predicate | Object |
|---|---|---|
| Tazarotene | INCREASES ACTIVITY OF | Retinoic Acid Receptor Alpha |
| Tazarotene | INCREASES ACTIVITY OF | Retinoic Acid Receptor Rxr-Beta |
| Tazarotene | INCREASES ACTIVITY OF | Retinoic Acid Receptor Gamma |
| Tazarotene | INCREASES ACTIVITY OF | Retinoic Acid Receptor Beta |
| Retinoic Acid Receptor Alpha | NEGATIVELY CORRELATED WITH | Epidermal Growth Factor Receptor |
| Retinoic Acid Receptor Rxr-Beta | NEGATIVELY CORRELATED WITH | Epidermal Growth Factor Receptor |
| Retinoic Acid Receptor Gamma | NEGATIVELY CORRELATED WITH | Epidermal Growth Factor Receptor |
| Retinoic Acid Receptor Beta | NEGATIVELY CORRELATED WITH | Epidermal Growth Factor Receptor |
| Retinoic Acid Receptor Alpha | NEGATIVELY CORRELATED WITH | Keratin-16 |
| Retinoic Acid Receptor Rxr-Beta | NEGATIVELY CORRELATED WITH | Keratin-16 |
| Retinoic Acid Receptor Gamma | NEGATIVELY CORRELATED WITH | Keratin-16 |
| Retinoic Acid Receptor Beta | NEGATIVELY CORRELATED WITH | Keratin-16 |
| Retinoic Acid Receptor Alpha | NEGATIVELY CORRELATED WITH | Keratin-6 |
| Retinoic Acid Receptor Rxr-Beta | NEGATIVELY CORRELATED WITH | Keratin-6 |
| Retinoic Acid Receptor Gamma | NEGATIVELY CORRELATED WITH | Keratin-6 |
| Retinoic Acid Receptor Beta | NEGATIVELY CORRELATED WITH | Keratin-6 |
| Retinoic Acid Receptor Alpha | NEGATIVELY CORRELATED WITH | Matrix Metalloproteinases |
| Retinoic Acid Receptor Rxr-Beta | NEGATIVELY CORRELATED WITH | Matrix Metalloproteinases |
| Retinoic Acid Receptor Gamma | NEGATIVELY CORRELATED WITH | Matrix Metalloproteinases |
| Retinoic Acid Receptor Beta | NEGATIVELY CORRELATED WITH | Matrix Metalloproteinases |
| Retinoic Acid Receptor Alpha | NEGATIVELY CORRELATED WITH | Toll Like Receptor 2 (Tlr2) Cascade |
| Retinoic Acid Receptor Rxr-Beta | NEGATIVELY CORRELATED WITH | Toll Like Receptor 2 (Tlr2) Cascade |
| Retinoic Acid Receptor Gamma | NEGATIVELY CORRELATED WITH | Toll Like Receptor 2 (Tlr2) Cascade |
| Retinoic Acid Receptor Beta | NEGATIVELY CORRELATED WITH | Toll Like Receptor 2 (Tlr2) Cascade |
| Toll Like Receptor 2 (Tlr2) Cascade | POSITIVELY CORRELATED WITH | Inflammatory Response |
| Epidermal Growth Factor Receptor | POSITIVELY CORRELATED WITH | Inflammatory Response |
| Keratin-16 | POSITIVELY CORRELATED WITH | Comedo |
| Keratin-6 | POSITIVELY CORRELATED WITH | Comedo |
| Comedo | POSITIVELY CORRELATED WITH | Acne Vulgaris |
| Inflammatory Response | POSITIVELY CORRELATED WITH | Acne Vulgaris |
| Matrix Metalloproteinases | POSITIVELY CORRELATED WITH | Acne Vulgaris |
Reference: