Path ID: DB00798_MESH_D016920_1
Concepts
| Identifier | Name | Type |
|---|---|---|
| MESH:D005839 | gentamicin | Drug |
| UniProt:P0A7S3 | 30S ribosomal protein S12 | Protein |
| MESH:D012336 | RNA, Ribosomal, 16S | ChemicalSubstance |
| MESH:D012338 | RNA, Ribosomal, 23S | ChemicalSubstance |
| GO:0006412 | translation | BiologicalProcess |
| taxonomy:2 | Bacteria | OrganismTaxon |
| MESH:D016920 | Meningitis, Bacterial | Disease |
Relationships
NOTE: predicates are annotated in Biolink Model (v1.3.0)
| Subject | Predicate | Object |
|---|---|---|
| Gentamicin | DECREASES ACTIVITY OF | 30S Ribosomal Protein S12 |
| Gentamicin | NEGATIVELY REGULATES | Rna, Ribosomal, 16S |
| Gentamicin | NEGATIVELY REGULATES | Rna, Ribosomal, 23S |
| 30S Ribosomal Protein S12 | PARTICIPATES IN | Translation |
| Rna, Ribosomal, 16S | PARTICIPATES IN | Translation |
| Rna, Ribosomal, 23S | PARTICIPATES IN | Translation |
| Translation | OCCURS IN | Bacteria |
| Bacteria | CAUSES | Meningitis, Bacterial |
Comment: Gentamicin is a bactericidal aminoglycoside that initialy binds to the bacterial outer membrane and then the cytoplasmic membrane for the entry into the bacterial cell.
Reference: