Path ID: DB00794_MESH_D004830_1
Concepts
| Identifier | Name | Type |
|---|---|---|
| MESH:D011324 | primidone | Drug |
| CHEBI:8069 | phenobarbital | ChemicalSubstance |
| CHEBI:8097 | Phenylethylmalonamide | ChemicalSubstance |
| InterPro:IPR006028 | Gamma-aminobutyric acid A receptor/Glycine receptor alpha | GeneFamily |
| GO:0022851 | GABA-gated chloride ion channel activity | MolecularActivity |
| GO:0060081 | membrane hyperpolarization | BiologicalProcess |
| GO:0019228 | neuronal action potential | BiologicalProcess |
| GO:0050806 | positive regulation of synaptic transmission | BiologicalProcess |
| MESH:D004830 | Tonic-clonic epilepsy | Disease |
Relationships
NOTE: predicates are annotated in Biolink Model (v1.3.0)
| Subject | Predicate | Object |
|---|---|---|
| Primidone | HAS METABOLITE | Phenobarbital |
| Primidone | HAS METABOLITE | Phenylethylmalonamide |
| Phenobarbital | INCREASES ACTIVITY OF | Gamma-Aminobutyric Acid A Receptor/Glycine Receptor Alpha |
| Phenylethylmalonamide | INCREASES ACTIVITY OF | Gamma-Aminobutyric Acid A Receptor/Glycine Receptor Alpha |
| Gamma-Aminobutyric Acid A Receptor/Glycine Receptor Alpha | POSITIVELY REGULATES | Gaba-Gated Chloride Ion Channel Activity |
| Gamma-Aminobutyric Acid A Receptor/Glycine Receptor Alpha | PARTICIPATES IN | Gaba-Gated Chloride Ion Channel Activity |
| Gaba-Gated Chloride Ion Channel Activity | POSITIVELY CORRELATED WITH | Membrane Hyperpolarization |
| Membrane Hyperpolarization | NEGATIVELY REGULATES | Neuronal Action Potential |
| Neuronal Action Potential | CONTRIBUTES TO | Positive Regulation Of Synaptic Transmission |
| Positive Regulation Of Synaptic Transmission | POSITIVELY CORRELATED WITH | Tonic-Clonic Epilepsy |
Comment: Primidone MoA is unknown. Its major metabolite are, phenobarbital and Phenylethylmalonamide, which are likely contributes to primidone’s effects in many forms of epilepsy.
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