Path ID: DB00790_MESH_D006973_1
Concepts
| Identifier | Name | Type |
|---|---|---|
| MESH:D020913 | Perindopril | Drug |
| MESH:C053500 | perindoprilat | ChemicalSubstance |
| UniProt:P12821 | Angiotensin-converting enzyme | Protein |
| MESH:D000804 | Angiotensin II | ChemicalSubstance |
| GO:0042310 | vasoconstriction | BiologicalProcess |
| HP:0032263 | Increased blood pressure | PhenotypicFeature |
| MESH:D006973 | Hypertension | Disease |
Relationships
NOTE: predicates are annotated in Biolink Model (v1.3.0)
| Subject | Predicate | Object |
|---|---|---|
| Perindopril | HAS METABOLITE | Perindoprilat |
| Perindoprilat | DECREASES ACTIVITY OF | Angiotensin-Converting Enzyme |
| Angiotensin-Converting Enzyme | PRODUCES | Angiotensin Ii |
| Angiotensin Ii | POSITIVELY REGULATES | Vasoconstriction |
| Vasoconstriction | CONTRIBUTES TO | Increased Blood Pressure |
| Increased Blood Pressure | POSITIVELY CORRELATED WITH | Hypertension |
Comment: Perindopril is a nonsulfhydryl prodrug of perindoprilat, which is used to treat hypertension.
Reference: