Path ID: DB00788_MESH_D020773_1
Concepts
| Identifier | Name | Type |
|---|---|---|
| MESH:D009288 | naproxen | Drug |
| UniProt:P23219 | Prostaglandin G/H synthase 1 | Protein |
| UniProt:P35354 | Prostaglandin G/H synthase 2 | Protein |
| GO:0001516 | prostaglandin biosynthetic process | BiologicalProcess |
| GO:0006954 | inflammatory response | BiologicalProcess |
| HP:0012531 | Pain | PhenotypicFeature |
| MESH:D020773 | Headache Disorders | Disease |
Relationships
NOTE: predicates are annotated in Biolink Model (v1.3.0)
| Subject | Predicate | Object |
|---|---|---|
| Naproxen | DECREASES ACTIVITY OF | Prostaglandin G/H Synthase 1 |
| Naproxen | DECREASES ACTIVITY OF | Prostaglandin G/H Synthase 2 |
| Prostaglandin G/H Synthase 1 | POSITIVELY REGULATES | Prostaglandin Biosynthetic Process |
| Prostaglandin G/H Synthase 2 | POSITIVELY REGULATES | Prostaglandin Biosynthetic Process |
| Prostaglandin Biosynthetic Process | POSITIVELY CORRELATED WITH | Inflammatory Response |
| Inflammatory Response | HAS PHENOTYPE | Pain |
| Pain | CONTRIBUTES TO | Headache Disorders |
Reference: