Path ID: DB00783_MESH_D065446_1
Concepts
| Identifier | Name | Type |
|---|---|---|
| MESH:D004958 | Estradiol | Drug |
| UniProt:P03372 | Estrogen receptor alpha | Protein |
| UniProt:Q92731 | Estrogen receptor beta | Protein |
| GO:0043627 | Response to estrogen | BiologicalProcess |
| MESH:D012701 | Serotonin | ChemicalSubstance |
| MESH:D019964 | Mood Disorders | Disease |
| MESH:D065446 | Premenstrual dysphoric disorder | Disease |
Relationships
NOTE: predicates are annotated in Biolink Model (v1.3.0)
| Subject | Predicate | Object |
|---|---|---|
| Estradiol | INCREASES ACTIVITY OF | Estrogen Receptor Alpha |
| Estradiol | INCREASES ACTIVITY OF | Estrogen Receptor Beta |
| Estrogen Receptor Alpha | PARTICIPATES IN | Response To Estrogen |
| Estrogen Receptor Beta | PARTICIPATES IN | Response To Estrogen |
| Response To Estrogen | INCREASES ABUNDANCE OF | Serotonin |
| Serotonin | NEGATIVELY CORRELATED WITH | Mood Disorders |
| Mood Disorders | POSITIVELY CORRELATED WITH | Premenstrual Dysphoric Disorder |
Reference: