Path ID: DB00771_MESH_D043183_1
Concepts
| Identifier | Name | Type |
|---|---|---|
| MESH:C054940 | clidinium | Drug |
| UniProt:P11229 | Muscarinic acetylcholine receptor M1 | Protein |
| GO:0006939 | smooth muscle contraction | BiologicalProcess |
| HP:0032155 | Abdominal cramps | PhenotypicFeature |
| MESH:D013035 | Spasm | BiologicalProcess |
| HP:0002579 | Gastrointestinal dysmotility | PhenotypicFeature |
| MESH:D043183 | Irritable bowel syndrome | Disease |
Relationships
NOTE: predicates are annotated in Biolink Model (v1.3.0)
| Subject | Predicate | Object |
|---|---|---|
| Clidinium | NEGATIVELY REGULATES | Muscarinic Acetylcholine Receptor M1 |
| Muscarinic Acetylcholine Receptor M1 | POSITIVELY REGULATES | Smooth Muscle Contraction |
| Smooth Muscle Contraction | POSITIVELY CORRELATED WITH | Spasm |
| Spasm | INCREASES ABUNDANCE OF | Abdominal Cramps |
| Abdominal Cramps | CORRELATED WITH | Gastrointestinal Dysmotility |
| Gastrointestinal Dysmotility | MANIFESTATION OF | Irritable Bowel Syndrome |
Reference: