Path ID: DB00771_MESH_D004760_1
Concepts
| Identifier | Name | Type |
|---|---|---|
| MESH:C054940 | clidinium | Drug |
| UniProt:P11229 | Muscarinic acetylcholine receptor M1 | Protein |
| GO:0006939 | smooth muscle contraction | BiologicalProcess |
| GO:0001696 | Intestinal Secretions | BiologicalProcess |
| HP:0003394 | Muscle spasm | PhenotypicFeature |
| MESH:D004760 | Enterocolitis | Disease |
Relationships
NOTE: predicates are annotated in Biolink Model (v1.3.0)
| Subject | Predicate | Object |
|---|---|---|
| Clidinium | NEGATIVELY REGULATES | Muscarinic Acetylcholine Receptor M1 |
| Muscarinic Acetylcholine Receptor M1 | POSITIVELY REGULATES | Smooth Muscle Contraction |
| Smooth Muscle Contraction | POSITIVELY CORRELATED WITH | Intestinal Secretions |
| Smooth Muscle Contraction | POSITIVELY CORRELATED WITH | Muscle Spasm |
| Intestinal Secretions | CORRELATED WITH | Enterocolitis |
| Muscle Spasm | CORRELATED WITH | Enterocolitis |
Comment: The disease, specially the acute form, is mainly caused by infection (https://en.wikipedia.org/wiki/Enterocolitis#Cause), leading to inflammation. So in addition to treating the symptoms (such as spams and GI secretions), antibiotics, anti-virals etc may be needed for treatment (https://en.wikipedia.org/wiki/Enterocolitis#Treatment).
Reference: