Path ID: DB00770_MESH_D000071079_1
Concepts
| Identifier | Name | Type |
|---|---|---|
| MESH:D000527 | Alprostadil | Drug |
| UniProt:P43116 | Prostaglandin E2 receptor EP2 subtype | Protein |
| GO:0007189 | Adenylate cyclase-activating G protein-coupled receptor signaling pathway | BiologicalProcess |
| GO:0044557 | Relaxation of smooth muscle | BiologicalProcess |
| GO:0042311 | Vasodilation | BiologicalProcess |
| GO:0008015 | Blood circulation | BiologicalProcess |
| MESH:D000071079 | Pulmonary artery stenosis | Disease |
Relationships
NOTE: predicates are annotated in Biolink Model (v1.3.0)
| Subject | Predicate | Object |
|---|---|---|
| Alprostadil | INCREASES ACTIVITY OF | Prostaglandin E2 Receptor Ep2 Subtype |
| Prostaglandin E2 Receptor Ep2 Subtype | POSITIVELY REGULATES | Adenylate Cyclase-Activating G Protein-Coupled Receptor Signaling Pathway |
| Adenylate Cyclase-Activating G Protein-Coupled Receptor Signaling Pathway | POSITIVELY REGULATES | Relaxation Of Smooth Muscle |
| Relaxation Of Smooth Muscle | POSITIVELY CORRELATED WITH | Vasodilation |
| Vasodilation | POSITIVELY CORRELATED WITH | Blood Circulation |
| Blood Circulation | NEGATIVELY CORRELATED WITH | Pulmonary Artery Stenosis |
Reference: