Path ID: DB00752_MESH_D003865_1
Concepts
| Identifier | Name | Type |
|---|---|---|
| MESH:D014191 | Tranylcypromine | Drug |
| UniProt:P27338 | Amine oxidase [flavin-containing] B | Protein |
| UniProt:P21397 | Amine oxidase [flavin-containing] A | Protein |
| MESH:D012701 | Serotonin | ChemicalSubstance |
| MESH:D004298 | Dopamine | ChemicalSubstance |
| MESH:D009638 | Norepinephrine | ChemicalSubstance |
| MESH:D003865 | Major depressive disorder | Disease |
Relationships
NOTE: predicates are annotated in Biolink Model (v1.3.0)
| Subject | Predicate | Object |
|---|---|---|
| Tranylcypromine | DECREASES ACTIVITY OF | Amine Oxidase [Flavin-Containing] B |
| Tranylcypromine | DECREASES ACTIVITY OF | Amine Oxidase [Flavin-Containing] A |
| Amine Oxidase [Flavin-Containing] A | NEGATIVELY REGULATES | Norepinephrine |
| Amine Oxidase [Flavin-Containing] A | NEGATIVELY REGULATES | Dopamine |
| Norepinephrine | NEGATIVELY CORRELATED WITH | Major Depressive Disorder |
| Amine Oxidase [Flavin-Containing] A | NEGATIVELY REGULATES | Serotonin |
| Serotonin | NEGATIVELY CORRELATED WITH | Major Depressive Disorder |
| Amine Oxidase [Flavin-Containing] B | NEGATIVELY REGULATES | Dopamine |
| Dopamine | NEGATIVELY CORRELATED WITH | Major Depressive Disorder |
Reference: