Path ID: DB00740_MESH_D000690_1
Concepts
| Identifier | Name | Type |
|---|---|---|
| MESH:D019782 | Riluzole | Drug |
| UniProt:Q14524 | Sodium channel protein type 5 subunit alpha | Protein |
| GO:0004972 | NMDA glutamate receptor activity | MolecularActivity |
| GO:0098719 | Sodium ion import across plasma membrane | BiologicalProcess |
| GO:0061535 | Glutamate secretion, neurotransmission | BiologicalProcess |
| GO:0070509 | Transmembrane calcium influx | BiologicalProcess |
| GO:0090280 | Positive regulation of calcium ion import | BiologicalProcess |
| GO:0051899 | Membrane depolarization | BiologicalProcess |
| GO:0070997 | Neuronal cell death | BiologicalProcess |
| MESH:D000690 | Amyotrophic lateral sclerosis | Disease |
Relationships
NOTE: predicates are annotated in Biolink Model (v1.3.0)
| Subject | Predicate | Object |
|---|---|---|
| Riluzole | DECREASES ACTIVITY OF | Sodium Channel Protein Type 5 Subunit Alpha |
| Riluzole | DECREASES ACTIVITY OF | Nmda Glutamate Receptor Activity |
| Sodium Channel Protein Type 5 Subunit Alpha | PARTICIPATES IN | Sodium Ion Import Across Plasma Membrane |
| Nmda Glutamate Receptor Activity | POSITIVELY REGULATES | Transmembrane Calcium Influx |
| Sodium Ion Import Across Plasma Membrane | CAPABLE OF | Positive Regulation Of Calcium Ion Import |
| Positive Regulation Of Calcium Ion Import | CONTRIBUTES TO | Membrane Depolarization |
| Membrane Depolarization | POSITIVELY REGULATES | Glutamate Secretion, Neurotransmission |
| Glutamate Secretion, Neurotransmission | POSITIVELY REGULATES | Nmda Glutamate Receptor Activity |
| Transmembrane Calcium Influx | POSITIVELY CORRELATED WITH | Neuronal Cell Death |
| Neuronal Cell Death | OCCURS IN | Amyotrophic Lateral Sclerosis |
Reference: