Path ID: DB00736_MESH_D015043_1
Concepts
| Identifier | Name | Type |
|---|---|---|
| MESH:D064098 | esomeprazole | Drug |
| UniProt:P20648 | Potassium-transporting ATPase alpha chain 1 | Protein |
| GO:0008900 | P-type potassium:proton transporter activity | MolecularActivity |
| GO:0001696 | gastric acid secretion | BiologicalProcess |
| HP:0002588 | Duodenal ulcer | PhenotypicFeature |
| HP:0004398 | Peptic Ulcer | PhenotypicFeature |
| MESH:D015043 | Zollinger-Ellison syndrome | Disease |
Relationships
NOTE: predicates are annotated in Biolink Model (v1.3.0)
| Subject | Predicate | Object |
|---|---|---|
| Esomeprazole | DECREASES ACTIVITY OF | Potassium-Transporting Atpase Alpha Chain 1 |
| Potassium-Transporting Atpase Alpha Chain 1 | POSITIVELY CORRELATED WITH | P-Type Potassium:Proton Transporter Activity |
| P-Type Potassium:Proton Transporter Activity | POSITIVELY CORRELATED WITH | Gastric Acid Secretion |
| Gastric Acid Secretion | POSITIVELY CORRELATED WITH | Peptic Ulcer |
| Gastric Acid Secretion | POSITIVELY CORRELATED WITH | Duodenal Ulcer |
| Duodenal Ulcer | MANIFESTATION OF | Zollinger-Ellison Syndrome |
| Peptic Ulcer | MANIFESTATION OF | Zollinger-Ellison Syndrome |
Comment: Esomeprazole is the s-isomer of Omeprazole, both are a proton pump inhibitor class of drug and the mechanism of action for both is similar. Weve annotated the path for the S isomer only as it seems this isomer is metabolized more slowly than omeprazole and therefore it will act for longer and more effectively (https://onlinelibrary.wiley.com/doi/pdf/10.1046/j.1365-2036.17.s1.1.x). This disease is denoted as Peptic reflux disease in the original file.
Reference:
- https://go.drugbank.com/drugs/DB00736#mechanism-of-action
- https://en.wikipedia.org/wiki/Esomeprazole
- https://en.wikipedia.org/wiki/Omeprazole#Mechanism_of_action
- https://en.wikipedia.org/wiki/Esophagitis#Causes
- https://en.wikipedia.org/wiki/Esophagitis#Medications
- https://en.wikipedia.org/wiki/Zollinger%E2%80%93Ellison_syndrome#Treatment
- https://en.wikipedia.org/wiki/Zollinger%E2%80%93Ellison_syndrome#Pathophysiology