Path ID: DB00731_MESH_D003924_1
Concepts
| Identifier | Name | Type |
|---|---|---|
| MESH:C060142 | Nateglinide | Drug |
| UniProt:Q09428 | ATP-binding cassette sub-family C member 8 | Protein |
| GO:0005267 | Potassium channel activity | MolecularActivity |
| GO:0060081 | Membrane hyperpolarization | BiologicalProcess |
| GO:0070509 | Transmembrane calcium influx | BiologicalProcess |
| GO:0030073 | Insulin secretion | BiologicalProcess |
| HP:0003074 | Hyperglycemia | PhenotypicFeature |
| MESH:D003924 | Diabetes mellitus type 2 | Disease |
Relationships
NOTE: predicates are annotated in Biolink Model (v1.3.0)
| Subject | Predicate | Object |
|---|---|---|
| Nateglinide | DECREASES ACTIVITY OF | Atp-Binding Cassette Sub-Family C Member 8 |
| Atp-Binding Cassette Sub-Family C Member 8 | REGULATES | Potassium Channel Activity |
| Potassium Channel Activity | PARTICIPATES IN | Membrane Hyperpolarization |
| Membrane Hyperpolarization | NEGATIVELY REGULATES | Transmembrane Calcium Influx |
| Transmembrane Calcium Influx | POSITIVELY REGULATES | Insulin Secretion |
| Insulin Secretion | NEGATIVELY CORRELATED WITH | Hyperglycemia |
| Hyperglycemia | MANIFESTATION OF | Diabetes Mellitus Type 2 |
Reference: