Path ID: DB00730_MESH_D001196_1
Concepts
| Identifier | Name | Type |
|---|---|---|
| MESH:D013827 | Thiabendazole | Drug |
| GO:0009061 | Anaerobic respiration | BiologicalProcess |
| InterPro:IPR005884 | Fumarate reductase, flavoprotein subunit | GeneFamily |
| taxonomy:6252 | Ascaris lumbricoides | OrganismTaxon |
| MESH:D001196 | Ascariasis | Disease |
Relationships
NOTE: predicates are annotated in Biolink Model (v1.3.0)
| Subject | Predicate | Object |
|---|---|---|
| Thiabendazole | DECREASES ACTIVITY OF | Fumarate Reductase, Flavoprotein Subunit |
| Fumarate Reductase, Flavoprotein Subunit | POSITIVELY REGULATES | Anaerobic Respiration |
| Anaerobic Respiration | IN TAXON | Ascaris Lumbricoides |
| Ascaris Lumbricoides | CAUSES | Ascariasis |
Comment: The precise mode of action of thiabendazole on the parasite is unknown, but it most likely inhibits the helminth-specific enzyme fumarate reductase.
Reference: