Path ID: DB00726_MESH_D003866_1
Concepts
| Identifier | Name | Type |
|---|---|---|
| MESH:D014299 | Trimipramine | Drug |
| UniProt:P35367 | Histamine H1 receptor | Protein |
| MESH:D006632 | Histamine | ChemicalSubstance |
| GO:0042421 | Norepinephrine biosynthetic proces | BiologicalProcess |
| GO:0030431 | Sleep | BiologicalProcess |
| GO:0061533 | Norepinephrine secretion, neurotransmission | BiologicalProcess |
| MESH:D003866 | Depressive disorder | Disease |
Relationships
NOTE: predicates are annotated in Biolink Model (v1.3.0)
| Subject | Predicate | Object |
|---|---|---|
| Trimipramine | DECREASES ACTIVITY OF | Histamine H1 Receptor |
| Trimipramine | POSITIVELY REGULATES | Norepinephrine Biosynthetic Proces |
| Histamine H1 Receptor | POSITIVELY CORRELATED WITH | Histamine |
| Histamine | NEGATIVELY REGULATES | Sleep |
| Norepinephrine Biosynthetic Proces | POSITIVELY CORRELATED WITH | Norepinephrine Secretion, Neurotransmission |
| Sleep | NEGATIVELY CORRELATED WITH | Depressive Disorder |
| Norepinephrine Secretion, Neurotransmission | NEGATIVELY CORRELATED WITH | Depressive Disorder |
Comment: The mechanism of action of trimipramine is not fully clear
Reference: