Path ID: DB00725_MESH_D043183_1
Concepts
| Identifier | Name | Type |
|---|---|---|
| MESH:C056244 | methylhomatropine | Drug |
| UniProt:P08172 | Muscarinic acetylcholine receptor M2 | Protein |
| UniProt:P20309 | Muscarinic acetylcholine receptor M3 | Protein |
| GO:0007197 | adenylate cyclase-inhibiting G protein-coupled acetylcholine receptor signaling pathway | BiologicalProcess |
| GO:0006939 | smooth muscle contraction | BiologicalProcess |
| HP:0032155 | Abdominal cramps | PhenotypicFeature |
| MESH:D043183 | Irritable bowel syndrome | Disease |
Relationships
NOTE: predicates are annotated in Biolink Model (v1.3.0)
| Subject | Predicate | Object |
|---|---|---|
| Methylhomatropine | NEGATIVELY REGULATES | Muscarinic Acetylcholine Receptor M2 |
| Methylhomatropine | NEGATIVELY REGULATES | Muscarinic Acetylcholine Receptor M3 |
| Muscarinic Acetylcholine Receptor M2 | PARTICIPATES IN | Adenylate Cyclase-Inhibiting G Protein-Coupled Acetylcholine Receptor Signaling Pathway |
| Muscarinic Acetylcholine Receptor M3 | PARTICIPATES IN | Adenylate Cyclase-Inhibiting G Protein-Coupled Acetylcholine Receptor Signaling Pathway |
| Adenylate Cyclase-Inhibiting G Protein-Coupled Acetylcholine Receptor Signaling Pathway | POSITIVELY CORRELATED WITH | Smooth Muscle Contraction |
| Smooth Muscle Contraction | POSITIVELY CORRELATED WITH | Abdominal Cramps |
| Abdominal Cramps | MANIFESTATION OF | Irritable Bowel Syndrome |
Reference: