Path ID: DB00716_MESH_D003233_1
Concepts
| Identifier | Name | Type |
|---|---|---|
| MESH:D017835 | Nedocromil | Drug |
| UniProt:Q9NS75 | Cysteinyl leukotriene receptor 2 | Protein |
| UniProt:Q9Y271 | Cysteinyl leukotriene receptor 1 | Protein |
| GO:0043303 | Mast cell degranulation | BiologicalProcess |
| MESH:D017998 | Leukotriene D4 | ChemicalSubstance |
| GO:0043117 | Positive regulation of vascular permeability | BiologicalProcess |
| GO:0006954 | Inflammatory response | BiologicalProcess |
| GO:0001821 | Histamine secretion | BiologicalProcess |
| MESH:D003233 | Allergic conjunctivitis | Disease |
Relationships
NOTE: predicates are annotated in Biolink Model (v1.3.0)
| Subject | Predicate | Object |
|---|---|---|
| Nedocromil | DECREASES ACTIVITY OF | Cysteinyl Leukotriene Receptor 2 |
| Nedocromil | DECREASES ACTIVITY OF | Cysteinyl Leukotriene Receptor 1 |
| Nedocromil | NEGATIVELY REGULATES | Mast Cell Degranulation |
| Cysteinyl Leukotriene Receptor 2 | POSITIVELY CORRELATED WITH | Leukotriene D4 |
| Cysteinyl Leukotriene Receptor 1 | POSITIVELY CORRELATED WITH | Leukotriene D4 |
| Mast Cell Degranulation | PRECEDES | Histamine Secretion |
| Leukotriene D4 | POSITIVELY REGULATES | Positive Regulation Of Vascular Permeability |
| Leukotriene D4 | POSITIVELY REGULATES | Inflammatory Response |
| Positive Regulation Of Vascular Permeability | MANIFESTATION OF | Allergic Conjunctivitis |
| Histamine Secretion | POSITIVELY REGULATES | Inflammatory Response |
| Inflammatory Response | MANIFESTATION OF | Allergic Conjunctivitis |
Reference: