Path ID: DB00709_MESH_D015658_1
Concepts
| Identifier | Name | Type |
|---|---|---|
| MESH:D019259 | lamivudine | Drug |
| MESH:C417268 | lamivudine triphosphate | ChemicalSubstance |
| UniProt:Q72547 | HIV-1 reverse transcriptase | Protein |
| GO:0003964 | RNA-directed DNA polymerase activity | MolecularActivity |
| GO:0019079 | viral genome replication | BiologicalProcess |
| taxonomy:11676 | Human immunodeficiency virus 1 | OrganismTaxon |
| MESH:D015658 | Human immunodeficiency virus infection | Disease |
Relationships
NOTE: predicates are annotated in Biolink Model (v1.3.0)
| Subject | Predicate | Object |
|---|---|---|
| Lamivudine | INCREASES ABUNDANCE OF | Lamivudine Triphosphate |
| Lamivudine Triphosphate | DECREASES ACTIVITY OF | Hiv-1 Reverse Transcriptase |
| Hiv-1 Reverse Transcriptase | POSITIVELY REGULATES | Rna-Directed Dna Polymerase Activity |
| Rna-Directed Dna Polymerase Activity | POSITIVELY CORRELATED WITH | Viral Genome Replication |
| Viral Genome Replication | IN TAXON | Human Immunodeficiency Virus 1 |
| Human Immunodeficiency Virus 1 | CAUSES | Human Immunodeficiency Virus Infection |
Reference: