Path ID: DB00704_MESH_D059350_1
Concepts
| Identifier | Name | Type |
|---|---|---|
| MESH:D009270 | Low Dose Naltrexone | Drug |
| UniProt:O00206 | Toll-like receptor 4 | Protein |
| UniProt:P01375 | Tumor necrosis factor | Protein |
| GO:0006954 | Inflammatory response | BiologicalProcess |
| MESH:D059350 | Chronic pain | Disease |
Relationships
NOTE: predicates are annotated in Biolink Model (v1.3.0)
| Subject | Predicate | Object |
|---|---|---|
| Low Dose Naltrexone | DECREASES ACTIVITY OF | Toll-Like Receptor 4 |
| Toll-Like Receptor 4 | INCREASES ACTIVITY OF | Tumor Necrosis Factor |
| Tumor Necrosis Factor | POSITIVELY REGULATES | Inflammatory Response |
| Inflammatory Response | POSITIVELY CORRELATED WITH | Chronic Pain |
Comment: It seems that only low doses of naltrexone has been documented to enhance or produce an analgesic response. Low-dose naltrexone (LDN) describes the off-label use of naltrexone at low doses for diseases not related to chemical dependency or intoxication. The annotation is for Low Dose Naltrexone (LDN).
Reference: